Timothy Weah scored at the 59 minutes into the friendly against Bolivia at Philadelphia’s Talen Energy Stadium.
The Paris St-Germain forward, 18, who was born in New York, and Josh Sargent, another Europe-based teen, were two of several new faces selected by interim US coach Dave Sarachan.
Weah made his debut for Paris Saint-Germain in March and got his first club start in the final match of the Ligue 1 season vs Caen (0-0), previously represented the US in the Under-17 World Cup and made his senior debut as a late substitute during a friendly win over Paraguay in March.
His goal came seven minutes after Sargent, who is yet to make his professional debut for German side Werder Bremen, pounced on a blunder by Bolivia goalkeeper Guillermo Viscarra to score on his international debut.
With no World Cup to play for, Dave Sarachan went with youth. He gave six players their debuts, raising the total to 15 in four matches since the Americans were eliminated in qualifying.